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Go to the shopThe bodily manifestations of ageing reflect changes that have occurred at the cellular level across all our organs. The changes in our cells have been extensively studied and classified as the hallmarks of ageing.
In the landmark paper by Lopez-Otin et al, Cell 153, 6 June 2013, the nine hallmarks of ageing were first described in detail. This framework was reviewed and updated in January 2023, adding three new hallmarks: disabled macroautophagy, chronic inflammation, and dysbiosis (Hallmarks of Aging Update, 19 January 2023).
Our product roadmap has been developed to target these hallmarks starting with the foundational piece, the immune system.
Unravelling the role of immunosenescence and why slowing or stopping the decline of our immune system is the key to increasing our healthspan. Ageing is a complex process influenced by various factors, and many of the hallmarks of ageing are affected by the state and health of the immune system.
CEO, Buck Institute for research on Aging
Our immune system serves as the body’s defence force, tirelessly working to protect us from pathogens and maintaining internal harmony. However, as we age, this once-vigilant system undergoes changes that compromise its efficiency. Immunosenescence encompasses alterations in both the innate and adaptive immune responses, leading to a decline in the body’s ability to recognise and combat threats.
The thymus, a crucial organ for T cell maturation, undergoes involution as we age, diminishing its ability to produce new, fully functional T cells. This decline hampers the adaptive immune response.
Ageing impairs the proliferation and function of immune cells, such as B cells and macrophages, contributing to a weakened defence against infections.
Chronic low-grade inflammation, termed inflammageing, becomes more prevalent with age. This persistent state of inflammation disrupts the delicate balance of cytokines, signalling molecules crucial for immune communication. Inflammation accelerates ageing.
Immunosenescence, the gradual decline of the immune system with age, accelerates telomere shortening, a key marker of cellular aging. Enhancing Immune function can help slow the rate of telomere shortening, preserve cellular health and promote longevity.
The waning immune function makes older individuals more susceptible to infections, leading to higher morbidity and mortality rates.
Vaccination, becomes much less effective in older individuals due to the weakened immune response.
The dysregulation of immune responses may contribute to the development of autoimmune disorders, where the immune system mistakenly attacks the body's own tissues.
A compromised immune surveillance system allows for the escape and proliferation of potentially cancerous cells, increasing the risk of cancer.
Understanding the pivotal role of immunosenescence in ageing emphasises the need for proactive measures to support immune health and immune health impacts all of the hallmarks of ageing. Ongoing research into supplements and peptides explore interventions to modulate the immune system and potentially reverse aspects of immunosenescence and this is what we are tackling at Aevum Labs. As research progresses, unlocking the secrets of immunosenescence holds promise for developing innovative strategies, supplements, lifestyle interventions and more to promote healthy ageing and improve the quality of life in our later years.
Through collaboration with leading longevity researchers, Re:juvenate brings together unique ingredients
Designed to optimize immune health with potent bioactives in an easy daily dose. Re:Juvenate is essential for daily support for your immune system.
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