The Science of Aging.

The bodily manifestations of ageing reflect changes that have occurred at the cellular level across all our organs. The changes in our cells have been extensively studied and classified as the hallmarks of ageing.

Pillars of Therapy

The Hallmarks of Ageing

In the landmark paper by Lopez-Otin et al, Cell 153, 6 June 2013, the nine hallmarks of ageing were first described in detail. This framework was reviewed and updated in January 2023, adding three new hallmarks: disabled macroautophagy, chronic inflammation, and dysbiosis (Hallmarks of Aging Update, 19 January 2023).

Our product roadmap has been developed to target these hallmarks starting with the foundational piece, the immune system.

The Foundation of Aging

Why it starts with the Immune System?

Unravelling the role of immunosenescence and why slowing or stopping the decline of our immune system is the key to increasing our healthspan. Ageing is a complex process influenced by various factors, and many of the hallmarks of ageing are affected by the state and health of the immune system.

“The immune system is a major driver of the aging process”

Dr Eric Verdin 
CEO, Buck Institute for research on Aging 

Core Pillar

The Immune System’s Central Role

Our immune system serves as the body’s defence force, tirelessly working to protect us from pathogens and maintaining internal harmony. However, as we age, this once-vigilant system undergoes changes that compromise its efficiency. Immunosenescence encompasses alterations in both the innate and adaptive immune responses, leading to a decline in the body’s ability to recognise and combat threats.

Key Factors in Immunosenescence

Thymic Involution

The thymus, a crucial organ for T cell maturation, undergoes involution as we age, diminishing its ability to produce new, fully functional T cells. This decline hampers the adaptive immune response.

Reduce Immune Cells

Ageing impairs the proliferation and function of immune cells, such as B cells and macrophages, contributing to a weakened defence against infections.

Cytokine Dysregulation

Chronic low-grade inflammation, termed inflammageing, becomes more prevalent with age. This persistent state of inflammation disrupts the delicate balance of cytokines, signalling molecules crucial for immune communication. Inflammation accelerates ageing.

Telomere shortening

Immunosenescence, the gradual decline of the immune system with age, accelerates telomere shortening, a key marker of cellular aging. Enhancing Immune function can help slow the rate of telomere shortening, preserve cellular health and promote longevity.

The Consequences

Susceptibility to Infections

The waning immune function makes older individuals more susceptible to infections, leading to higher morbidity and mortality rates.

Impaired Vaccine Responses

Vaccination, becomes much less effective in older individuals due to the weakened immune response.

Autoimmune Disorders

The dysregulation of immune responses may contribute to the development of autoimmune disorders, where the immune system mistakenly attacks the body's own tissues.

Cancer Susceptibility

A compromised immune surveillance system allows for the escape and proliferation of potentially cancerous cells, increasing the risk of cancer.

Without a well-functioning immune system we are susceptible to all the diseases of ageing so it’s fundamental to any longevity regime to address this first.

The Science of Aging

Understanding the pivotal role of immunosenescence in ageing emphasises the need for proactive measures to support immune health and immune health impacts all of the hallmarks of ageing. Ongoing research into supplements and peptides explore interventions to modulate the immune system and potentially reverse aspects of immunosenescence and this is what we are tackling at Aevum Labs. As research progresses, unlocking the secrets of immunosenescence holds promise for developing innovative strategies, supplements, lifestyle interventions and more to promote healthy ageing and improve the quality of life in our later years.

Innovative Ingredients

Immunel

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KawaKawa

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Rosemary

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  • Re:juvenate Pro
  • Re:juvenate Pro
  • Re:juvenate Pro
  • Re:juvenate Pro
  • Re:juvenate Pro

Re:juvenate Pro

$89.00 NZD
$89.00 NZD
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Description

The ultimate foundational supplement for promoting longevity, Re:juvenate Pro is designed to modulate the immune system for optimal health as we age. Science has repeatedly shown that a strong immune system is foundational for good health. Re:juvenate Pro takes the best of nature with four potent extracts, formulated for immune health.