Systemic Immune-Inflammation Index Calculator
Track changes in your systemic immune-inflammation status over time with a simple, private tool built from three values on a standard blood test.
What is the Systemic Immune-Inflammation Index?
The SII is a biomarker drawn from three values on a standard Complete Blood Count (CBC). Together they give a simple snapshot of the balance between your body’s inflammatory and immune-regulating activity — a useful number to track over time alongside how you feel.
SII = (Platelets × Neutrophils) ÷ Lymphocytes
All three values are taken from the same CBC test, measured in ×10ⁿ/L (or K/µL).
How to use this calculator
Get a Complete Blood Count (CBC) from your healthcare provider or lab.
Find your platelet, neutrophil and lymphocyte values on the report.
Enter each value below using the ×10ⁿ/L (or K/µL) figures.
Select Calculate to see your SII and an educational interpretation.
Calculate your SII
Enter the three values from your most recent CBC. Nothing is stored or sent — the calculation happens entirely in your browser.
Typical adult range ~150–400
Absolute count, ~2.0–7.0
Absolute count, ~1.0–3.0
Understanding your result
Typically reflects low systemic inflammation and well-balanced immune function.
May reflect mild or early inflammatory activity. A good prompt to review lifestyle factors and monitor the trend.
May reflect greater immune activation. Best discussed with your healthcare provider in context.
Supporting a balanced immune response
Anti-inflammatory eating
Lean into omega-3-rich foods, colourful vegetables, fruit and whole grains; ease off ultra-processed foods and added sugar.
Regular movement
Moderate, consistent physical activity helps regulate immune function and supports a healthy inflammatory balance.
Quality sleep
Aim for 7–9 hours of restful sleep to support recovery and day-to-day immune regulation.
Stress management
Practices like breathwork, meditation or yoga can help support a calmer inflammatory response.
Targeted nutrients
Some people choose supplements such as Re:juvenate Pro, vitamin D and omega-3s to support immune balance. Talk to your practitioner about what suits you.
Fewer toxins
Limiting smoking, excess alcohol and environmental toxins helps reduce unnecessary inflammatory load.
Daily immune support for a demanding world
Re:juvenate Pro pairs four researched bioactives in one easy daily dose — formulated to support immune balance as part of a healthy routine.
- This calculator is for educational purposes and does not replace professional medical advice, diagnosis or treatment.
- SII values should be interpreted by a qualified healthcare professional alongside your history and symptoms.
- Individual factors — age, medications, recent illness and lab methodology — can all affect results.
- Do not make health decisions based on this calculator alone. If you have concerns, speak with your provider.
Aevum Labs develops pharma-grade supplements for healthy ageing, and builds simple tools to help people understand their own biomarkers. This calculator is offered as an educational resource — for personalised guidance, always consult your healthcare provider.