Research – Aevum

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Research Hub

Below you'll find our research hub, we are constantly exploring research in the longevity space and collect reference materials related to our products below.

Research Papers

Immune Defense Proteins

Adam, K. H., & Claycomb, R. (2021). In vitro antiviral effects of milk derived bioactive whey proteins. Food New Zealand (December/January), 30–33.

Ulluwishewa, D., Mullaney, J., Adam, K., Claycomb, R., & Anderson, R. C. (2022). A bioactive bovine whey protein extract improves intestinal barrier function in vitro. JDS Communications.

Willems, E. et al. (2025). Effects of whey protein treatment in an in vitro intestinal cell model following oxidative stress or inflammatory challenge. International Dairy Journal, 164, 106187.

Rachel Page, Yongsijia Wei, Cheryl Gammon, Judy Thomas, Tasnima Akter, Katharine Helen Adam, Rodney Claycomb, Colin Roger Ogle, & Kay Rutherfurd-Markwick. (2024). Impact of IDP® on Enhancing Immune Response to the Influenza Vaccine: A Double-Blind, Randomized, Placebo Controlled, Pilot Study. Journal of Immunology and Infectious Diseases, 11(1): 102.

Singh, P., Dhakal, J., & Kumar, P. (2024). Antiviral properties of milk proteins and peptides against SARS-CoV-2: A review. Journal of Functional Foods, 117, 106237.

Immunel

NK cytotoxicity assays and CD107a degranulation assay. J Immunol Methods. 2011 Sep 30;372(1-2):187-95.

Borrego F, Robertson MJ, Ritz J, Peña J, Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor. Immunology. 1999 May;97(1):159-65.

Clausen J, Vergeiner B, Enk M, Petzer AL, Gastl G, Gunsilius E. Functional significance of the activation-associated receptors CD25 and CD69 on human NK-cells and NK-like T-cells. Immunobiology. 2003;207(2):85-93.

Jensen GS, Hart AN. Immunomodulation by SanPharma fungal metabolic products. J Altern Complement Med. 2006 May;12(4):409-16.

Hart AN, Zaske LA, Patterson KM, Drapeau C, Jensen GS. Natural killer cell activation and modulation of chemokine receptor profile in vitro by an extract from the cyanophyta Aphanizomenon flos-aquae. J Med Food. 2007 Sep;10(3):435-41.

Jensen GS, Patterson KM, Yoon I. Yeast culture has anti-inflammatory effects and specifically activates NK cells. Comp Immunol Microbiol Infect Dis. 2008 Nov;31(6):487-500.

Benson KF, Carter SG, Patterson KM, Patel D, Jensen GS. A novel extract from bovine colostrum whey supports anti-bacterial and anti-viral innate immune functions in vitro and in vivo: I. Enhanced immune activity in vitro translates to improved microbial clearance in animal infection models. Prev Med. 2012 May;54 Suppl:S116-23.

Benson KF, Beaman JL, Ou B, Okubena A, Okubena O, Jensen GS. West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro. J Med Food. 2013 Mar;16(3):230-8.

Benson KF, Newman RA, Jensen GS. Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (nae-8(®)). Clin Cosmet Investig Dermatol. 2015 May 6;8:239-48.

Benson KF, Newman RA, Jensen GS. Water-soluble egg membrane enhances the immunoactivating properties of an Aloe vera-based extract of Nerium oleander leaves. Clin Cosmet Investig Dermatol. 2016 Nov 3;9:393-403.

Jensen GS, Redman KA, Benson KF, Carter SG, Mitzner MA, Reeves S, Robinson L. Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food. 2011 Sep;14(9):1002-10.

Jensen GS, Patel D, Benson KF. A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans. Prev Med. 2012 May;54 Suppl:S124-9.

KawaKawa

Exploring the Chemical Space of Kawakawa Leaf (Piper excelsum)

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals

Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population

Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum

Anti-Inflammatory and Anti-Cancer Effects of Kawakawa (Macropiper excelsum) Leaves

Anti-inflammatory Effects of Kawakawa (Piper excelsum): An Integrative mRNA–miRNA Approach

Composition and Safety Evaluation of Tea from New Zealand Kawakawa (Piper excelsum)

Rosemary Extract

Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation

Carnosic acid: an effective phenolic diterpenoid for prevention and management of cancers via targeting multiple signaling pathways

Carnosic acid protects against lipopolysaccharide-induced acute lung injury in mice

The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM

Carnosic acid, a novel food-source AT1R antagonist and its anti-hypertension mechanism

Recent updates on antidiabetic and antiobesity potential of carnosic acid

Multi-Target Effects of β-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration

A Deep Insight in the Antioxidant Property of Carnosic Acid: From Computational Study to Experimental Analysis

Carnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation

Carnosic acid promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress and apoptosis in mice

Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action

Neuroprotective Effects of Carnosic Acid in an Experimental Model of Alzheimer’s Disease

Carnosic acid and carnosol: Neuroprotection and the mitochondria

Carnosic acid mitigates early brain injury after subarachnoid hemorrhage: possible involvement of the SIRT1/p66shc signaling pathway

The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats

Neuroprotection Comparison of Rosmarinic Acid and Carnosic Acid in Primary Cultures of Cerebellar Granule Neurons

Relevance of carnosic acid to the treatment of several health disorders: Molecular targets and mechanisms

Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes

Naturally-occurring carnosic acid as a promising therapeutic agent for skin inflammation via targeting STAT1

Proapoptotic, Anti-Cell Proliferative, Anti-Inflammatory and Anti-Angiogenic Potential of Carnosic Acid during 7,12 Dimethylbenz[a]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS

Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms

Carnosic acid induces apoptosis and suppresses invasion through ROS/JNK and mTOR signaling in human colorectal cancer cells

Carnosic acid suppresses inflammation and oxidative stress in a rat model of periodontitis

Carnosic acid prevents dextran sulfate sodium-induced murine experimental colitis via the downregulation of the NF-κB pathway

Carnosic acid exerts anti-cancer properties in human hepatoma HepG2 cells via induction of p53-mediated apoptosis and inhibition of NF-κB-mediated invasion

Carnosic acid induces mTOR- and ER stress-dependent autophagy in human non-small cell lung cancer cells

Carnosic acid suppresses the growth of human hepatocellular carcinoma HepG2 cells via inhibition of cell proliferation and induction of apoptosis

Carnosic acid induces apoptosis and suppresses migration of human gastric cancer cells via down-regulating phosphorylated Akt and phosphorylated Erk1/2

Colostrum

Colostrum supplement, immune variables and hospital-acquired infection in acute respiratory failure: A double-blind, randomized, placebo-controlled trial.

Oral Colostrum and Its Effect on Immune System.

A Review: The Effect of Bovine Colostrum on Immunity in People of All Ages.

Bovine colostrum as a biologic in clinical medicine: a review--Part II: clinical studies.

Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial.

Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial.

Colostrum Therapy for Human Gastrointestinal Health and Disease.

Bovine colostrum is a health food supplement which prevents NSAID induced gut damage.

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome.

Effects of Long-Term Supplementation of Bovine Colostrum on Iron Homeostasis, Oxidative Stress, and Inflammation in Female Athletes: A Placebo-Controlled Clinical Trial.

The Effects of 12 Weeks Colostrum Milk Supplementation on the Expression Levels of Pro-Inflammatory Mediators and Metabolic Changes among Older Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Antioxidant Properties of Human Colostrum.

Oral bovine colostrum supplementation does not increase circulating insulin-like growth factor-1 concentration in healthy adults: results from two randomized, placebo-controlled studies.

Role of Bovine Colostrum Dressing on Chronic Non-Healing Wounds in Comparison to Conventional Dressing: A Case-Control Study.

Role of Bovine Colostrum in Healing of Chronic Non-Healing Ulcers – A Clinical Study.

Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.

The study of growth factors in human colostrum.

Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy.

Colostrum Meets the Microbiome: A Tried and True Remedy for Gut Health Takes Centre Stage.

Colostrum Research - Growth Factors.

Colostrum & Wound Healing.

Colostrum Therapy for Human Gastrointestinal Health and Disease.

Effect of Colostrum on the Immune System in Healthy Adults.